Comprehensive modelling of the Neurospora circadian clock and its temperature compensation.

ABSTRACT: Circadian clocks provide an internal measure of external time allowing organisms to anticipate and exploit predictable daily changes in the environment. Rhythms driven by circadian clocks have a temperature compensated periodicity of approximately 24 hours that persists in constant conditions and can be reset by environmental time cues. Computational modelling has aided our understanding of the molecular mechanisms of circadian clocks, nevertheless it remains a major challenge to integrate the large number of clock components and their interactions into a single, comprehensive model that is able to account for the full breadth of clock phenotypes. Here we present a comprehensive dynamic model of the Neurospora crassa circadian clock that incorporates its key components and their transcript

SUBMITTER: Tseng YY 

PROVIDER: S-EPMC3320131 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature