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Functional complexity and regulation through RNA dynamics.

ABSTRACT: Changes to the conformation of coding and non-coding RNAs form the basis of elements of genetic regulation and provide an important source of complexity, which drives many of the fundamental processes of life. Although the structure of RNA is highly flexible, the underlying dynamics of RNA are robust and are limited to transitions between the few conformations that preserve favourable base-pairing and stacking interactions. The mechanisms by which cellular processes harness the intrinsic dynamic behaviour of RNA and use it within functionally productive pathways are complex. The versatile functions and ease by which it is integrated into a wide variety of genetic circuits and biochemical pathways suggests there is a general and fundamental role for RNA dynamics in cellular processes.

SUBMITTER: Dethoff EA

PROVIDER: S-EPMC3320162 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature

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Functional complexity and regulation through RNA dynamics.

Dethoff Elizabeth A EA Chugh Jeetender J Mustoe Anthony M AM Al-Hashimi Hashim M HM

Nature 20120215 7385

Changes to the conformation of coding and non-coding RNAs form the basis of elements of genetic regulation and provide an important source of complexity, which drives many of the fundamental processes of life. Although the structure of RNA is highly flexible, the underlying dynamics of RNA are robust and are limited to transitions between the few conformations that preserve favourable base-pairing and stacking interactions. The mechanisms by which cellular processes harness the intrinsic dynamic ...[more]

PMID: 22337051

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