Ontology highlight
ABSTRACT:
SUBMITTER: Bothe JR
PROVIDER: S-EPMC3320163 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Bothe Jameson R JR Nikolova Evgenia N EN Eichhorn Catherine D CD Chugh Jeetender J Hansen Alexandar L AL Al-Hashimi Hashim M HM
Nature methods 20111028 11
Many recently discovered noncoding RNAs do not fold into a single native conformation but sample many different conformations along their free-energy landscape to carry out their biological function. Here we review solution-state NMR techniques that measure the structural, kinetic and thermodynamic characteristics of RNA motions spanning picosecond to second timescales at atomic resolution, allowing unprecedented insights into the RNA dynamic structure landscape. From these studies a basic descr ...[more]