Ontology highlight
ABSTRACT:
SUBMITTER: Snyder JP
PROVIDER: S-EPMC33206 | biostudies-literature | 2001 Apr
REPOSITORIES: biostudies-literature
Snyder J P JP Nettles J H JH Cornett B B Downing K H KH Nogales E E
Proceedings of the National Academy of Sciences of the United States of America 20010417 9
The chemotherapeutic drug Taxol is known to interact within a specific site on beta-tubulin. Although the general location of the site has been defined by photoaffinity labeling and electron crystallography, the original data were insufficient to make an absolute determination of the bound conformation. We have now correlated the crystallographic density with analysis of Taxol conformations and have found the unique solution to be a T-shaped Taxol structure. This T-shaped or butterfly structure ...[more]