Ontology highlight
ABSTRACT:
SUBMITTER: Duverger O
PROVIDER: S-EPMC3320974 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Duverger Olivier O Zah Angela A Isaac Juliane J Sun Hong-Wei HW Bartels Anne K AK Lian Jane B JB Berdal Ariane A Hwang Joonsung J Morasso Maria I MI
The Journal of biological chemistry 20120220 15
During development, Dlx3 is expressed in ectodermal appendages such as hair and teeth. Thus far, the evidence that Dlx3 plays a crucial role in tooth development comes from reports showing that autosomal dominant mutations in DLX3 result in severe enamel and dentin defects leading to abscesses and infections. However, the normal function of DLX3 in odontogenesis remains unknown. Here, we use a mouse model to demonstrate that the absence of Dlx3 in the neural crest results in major impairment of ...[more]