Ontology highlight
ABSTRACT:
SUBMITTER: Kim D
PROVIDER: S-EPMC3320999 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Kim Dongkyun D Song Jinsoo J Kim Sunhyo S Park Hyang Mi HM Chun Churl-Hong CH Sonn Jongkyung J Jin Eun-Jung EJ
The Journal of biological chemistry 20120220 15
MicroRNAs (miRNAs) have been implicated in various cellular processes, such as cell fate determination, cell death, and tumorigenesis. In the present study, we investigated the role of miRNA-34a (miR-34a) in the reorganization of the actin cytoskeleton, which is essential for chondrocyte differentiation. miRNA arrays to identify genes that appeared to be up-regulated or down-regulated during chondrogenesis were applied with chondrogenic progenitors treated with JNK inhibitor. PNA-based antisense ...[more]