Ontology highlight
ABSTRACT:
SUBMITTER: Metzger T
PROVIDER: S-EPMC3321085 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Metzger Thomas T Gache Vincent V Xu Mu M Cadot Bruno B Folker Eric S ES Richardson Brian E BE Gomes Edgar R ER Baylies Mary K MK
Nature 20120318 7392
The basic unit of skeletal muscle in all metazoans is the multinucleate myofibre, within which individual nuclei are regularly positioned. The molecular machinery responsible for myonuclear positioning is not known. Improperly positioned nuclei are a hallmark of numerous diseases of muscle, including centronuclear myopathies, but it is unclear whether correct nuclear positioning is necessary for muscle function. Here we identify the microtubule-associated protein ensconsin (Ens)/microtubule-asso ...[more]