Ontology highlight
ABSTRACT:
SUBMITTER: Gulbransen BD
PROVIDER: S-EPMC3321107 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Nature medicine 20120318 4
Inflammatory bowel diseases (IBDs) are chronic relapsing and remitting conditions associated with long-term gut dysfunction resulting from alterations to the enteric nervous system and a loss of enteric neurons. The mechanisms underlying inflammation-induced enteric neuron death are unknown. Here using in vivo models of experimental colitis we report that inflammation causes enteric neuron death by activating a neuronal signaling complex composed of P2X7 receptors (P2X7Rs), pannexin-1 (Panx1) ch ...[more]