Ontology highlight
ABSTRACT:
SUBMITTER: Scholefield G
PROVIDER: S-EPMC3321191 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Scholefield Graham G Errington Jeff J Murray Heath H
The EMBO journal 20120127 6
Control of DNA replication initiation is essential for normal cell growth. A unifying characteristic of DNA replication initiator proteins across the kingdoms of life is their distinctive AAA+ nucleotide-binding domains. The bacterial initiator DnaA assembles into a right-handed helical oligomer built upon interactions between neighbouring AAA+ domains, that in vitro stretches DNA to promote replication origin opening. The Bacillus subtilis protein Soj/ParA has previously been shown to regulate ...[more]