Ontology highlight
ABSTRACT:
SUBMITTER: Mullin AP
PROVIDER: S-EPMC3321231 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Mullin Ariana P AP Gokhale Avanti A Larimore Jennifer J Faundez Victor V
Molecular neurobiology 20110426 1
There is growing interest in the biology of dysbindin and its genetic locus (DTNBP1) due to genetic variants associated with an increased risk of schizophrenia. Reduced levels of dysbindin mRNA and protein in the hippocampal formation of schizophrenia patients further support involvement of this locus in disease risk. Here, we discuss phylogenetically conserved dysbindin molecular interactions that define its contribution to the assembly of the biogenesis of lysosome-related organelles complex-1 ...[more]