Regenerative therapies for diabetic microangiopathy.
Ontology highlight
ABSTRACT:
SUBMITTER: Bassi R
PROVIDER: S-EPMC3321284 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Publications
Regenerative therapies for diabetic microangiopathy.
Bassi Roberto R Trevisani Alessio A Tezza Sara S Ben Nasr Moufida M Gatti Francesca F Vergani Andrea A Farina Antonio A Fiorina Paolo P
Experimental diabetes research 20120329
Hyperglycaemia occurring in diabetes is responsible for accelerated arterial remodeling and atherosclerosis, affecting the macro- and the microcirculatory system. Vessel injury is mainly related to deregulation of glucose homeostasis and insulin/insulin-precursors production, generation of advanced glycation end-products, reduction in nitric oxide synthesis, and oxidative and reductive stress. It occurs both at extracellular level with increased calcium and matrix proteins deposition and at intr ...[more]
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