Ontology highlight
ABSTRACT:
SUBMITTER: Wang L
PROVIDER: S-EPMC3321374 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Wang Lie L Carr Tiffany T Xiong Yumei Y Wildt Kathryn F KF Zhu Jinfang J Feigenbaum Lionel L Bendelac Albert A Bosselut Rémy R
European journal of immunology 20100901 9
While most CD4(+) T cells are MHC class II-restricted, a small subset, including the CD1d-restricted 'invariant' NKT (iNKT) cells, are selected on non-classical MHC-I or MHC-I-like molecules. We previously showed that the sequential activity of two zinc finger transcription factors, Gata3 and Thpok, promotes the differentiation of conventional, MHC II-restricted thymocytes into CD4(+) T cells. In the current study, we show that a Gata3-Thpok cascade is required for the differentiation of CD4(+) ...[more]