Ontology highlight
ABSTRACT:
SUBMITTER: Freshour J
PROVIDER: S-EPMC3321484 | biostudies-literature | 2007 Feb
REPOSITORIES: biostudies-literature
Freshour Judy J Yokoyama Ruth R Mitchell David R DR
The Journal of biological chemistry 20061227 8
We previously found that a mutation at the ODA7 locus in Chlamydomonas prevents axonemal outer row dynein assembly by blocking association of heavy chains and intermediate chains in the cytoplasm. We have now cloned the ODA7 locus by walking in the Chlamydomonas genome from nearby molecular markers, confirmed the identity of the gene by rescuing the mutant phenotype with genomic clones, and identified the ODA7 gene product as a 58-kDa leucine-rich repeat protein unrelated to outer row dynein LC1 ...[more]