Relationship between interleukin 18 polymorphisms and susceptibility to chronic hepatitis B virus infection.

ABSTRACT:

Aim

To identify the relationship between the tagging single nucleotide polymorphism sites (tagSNPs) of the Interleukin-18 (IL-18) gene and genetic susceptibility to chronic hepatitis B virus infection in Chinese patients.

Methods

Five hundred and one cases of chronic hepatitis B virus (HBV) infection and 301 HBV natural clearance controls were studied. Two tagSNPs in the IL-18 gene (rs1946518A/C and rs574424C/G) were genotyped by the Multiplex Snapshot technique. The genotype and allele frequencies were calculated and analyzed.

Results

In the genotypes of rs1946518, the AA type was present at a higher frequency in the patients compared to those in the controls. Odds ratio (OR) of the AA genotype for the comparison with that of the AC and the CC genotype was 1.537 (95%

SUBMITTER: Li N 

PROVIDER: S-EPMC3321489 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature