An investigation of candidate regions for association with bipolar disorder.
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ABSTRACT:
SUBMITTER: Knight J
PROVIDER: S-EPMC3321541 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Publications
An investigation of candidate regions for association with bipolar disorder.
Knight Jo J Rochberg Nanette S NS Saccone Scott F SF Nurnberger John I JI Rice John P JP
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 20101001 7
We performed a case-control study of 1,000 cases and 1,028 controls on 1,509 markers, 1,139 of which were located in a 8 Mb region on chromosome 6 (105-113 Mb). This region has shown evidence of involvement in bipolar disorder (BP) in a number of other studies. We find association between BP and two SNPs in the gene LACE1. SNP rs9486880 and rs11153113 (both have P-values of 2 × 10(-5)). Both P-values are in the top 5% of the distribution derived from null simulations (P = 0.02 and 0.01, respecti ...[more]
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