Ontology highlight
ABSTRACT:
SUBMITTER: Liao X
PROVIDER: S-EPMC3322248 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Liao Xianghai X Sluimer Judith C JC Wang Ying Y Subramanian Manikandan M Brown Kristy K Pattison J Scott JS Robbins Jeffrey J Martinez Jennifer J Tabas Ira I
Cell metabolism 20120322 4
In advanced atherosclerosis, macrophage apoptosis coupled with defective phagocytic clearance of the apoptotic cells (efferocytosis) promotes plaque necrosis, which precipitates acute atherothrombotic cardiovascular events. Oxidative and endoplasmic reticulum (ER) stress in macrophages are important causes of advanced lesional macrophage apoptosis. We now show that proapoptotic oxidative/ER stress inducers trigger another stress reaction in macrophages, autophagy. Inhibition of autophagy by sile ...[more]