Ontology highlight
ABSTRACT:
SUBMITTER: Grutter MG
PROVIDER: S-EPMC3322363 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Grütter Markus G MG Luban Jeremy J
Current opinion in virology 20120305 2
TRIM5 is a restriction factor that blocks retrovirus infection soon after the virion core enters the cell cytoplasm. Restriction activity is targeted to the virion core via recognition of the capsid protein lattice that encases the viral genomic RNA. In common with all of the many TRIM family members, TRIM5 has RING, B-box, and coiled-coil domains. As an E3 ubiquitin ligase TRIM5 cooperates with the heterodimeric E2, UBC13/UEV1A, to activate the TAK1 (MAP3K7) kinase, NF-κB and AP-1 signaling, an ...[more]