Ontology highlight
ABSTRACT:
SUBMITTER: Lopes-Marques M
PROVIDER: S-EPMC3322402 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
DNA and cell biology 20111104 4
Mutations in the untranslated regulatory regions of genes may result in abnormal gene expression or transcriptional regulation. In this study, we characterize the ornithine transcarbamylase (OTC) mRNA isoforms of the X-linked OTC gene involved in the urea formation in the liver. Our data revealed that two major transcripts (OTC-t1 and OTC-t2) are more highly expressed than any of the other isoforms in all the tissues analyzed, though a longer transcript (OTC-t3) was also isolated and characteriz ...[more]