Ontology highlight
ABSTRACT:
SUBMITTER: Han BG
PROVIDER: S-EPMC3322819 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
The Journal of biological chemistry 20120212 14
Apoptosis inhibitor 5 (API5) is an anti-apoptotic protein that is up-regulated in various cancer cells. Here, we present the crystal structure of human API5. API5 exhibits an elongated all α-helical structure. The N-terminal half of API5 is similar to the HEAT repeat and the C-terminal half is similar to the ARM (Armadillo-like) repeat. HEAT and ARM repeats have been implicated in protein-protein interactions, suggesting that the cellular roles of API5 may be to mediate protein-protein interacti ...[more]