Ontology highlight
ABSTRACT:
SUBMITTER: Whitham M
PROVIDER: S-EPMC3322851 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Whitham Martin M Chan M H Stanley MH Pal Martin M Matthews Vance B VB Prelovsek Oja O Lunke Sebastian S El-Osta Assam A El-Osta Assam A Broenneke Hella H Alber Jens J Brüning Jens C JC Wunderlich F Thomas FT Lancaster Graeme I GI Febbraio Mark A MA
The Journal of biological chemistry 20120218 14
Exercise increases the expression of the prototypical myokine IL-6, but the precise mechanism by which this occurs has yet to be identified. To mimic exercise conditions, C2C12 myotubes were mechanically stimulated via electrical pulse stimulation (EPS). We compared the responses of EPS with the pharmacological Ca(2+) carrier calcimycin (A23187) because contraction induces marked increases in cytosolic Ca(2+) levels or the classical IκB kinase/NFκB inflammatory response elicited by H(2)O(2). We ...[more]