Baseline quality of life as a prognostic survival tool in patients receiving sunitinib for metastatic renal cell carcinoma.

ABSTRACT:

Background

In a randomized phase III trial of sunitinib vs interferon-alfa (IFN-α) in metastatic renal cell carcinoma (mRCC), better baseline quality of life (QoL) was predictive of longer survival. Using this dataset, we have developed a novel prognostic tool that establishes a relationship between baseline QoL scores and median survival time.

Methods

Baseline QoL was assessed using the FACT-Kidney Symptom Index-15 item (FKSI-15), its disease-related symptoms (FKSI-DRS) subscale, and the Functional Assessment of Cancer Therapy-General (FACT-G) scale. Weibull models estimated median progression-free survival (mPFS) and overall survival (mOS) as a function of baseline QoL.

Results

Longer PFS and OS were associated with higher baseline FKSI-15, FKSI-DRS, and FACT-G scor

SUBMITTER: Cella D 

PROVIDER: S-EPMC3322947 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature