Ontology highlight
ABSTRACT:
SUBMITTER: Gruninger RJ
PROVIDER: S-EPMC3323020 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
The Journal of biological chemistry 20111202 13
Protein-tyrosine phosphatase-like inositol polyphosphatases are microbial enzymes that catalyze the stepwise removal of one or more phosphates from highly phosphorylated myo-inositols via a relatively ordered pathway. To understand the substrate specificity and kinetic mechanism of these enzymes we have determined high resolution, single crystal, x-ray crystallographic structures of inactive Selenomonas ruminantium PhyA in complex with myo-inositol hexa- and pentakisphosphate. These structures p ...[more]