Unknown

Dataset Information

0

Tfb6, a previously unidentified subunit of the general transcription factor TFIIH, facilitates dissociation of Ssl2 helicase after transcription initiation.


ABSTRACT: General transcription factor TFIIH, previously described as a 10-subunit complex, is essential for transcription and DNA repair. An eleventh subunit now identified, termed Tfb6, exhibits 45% sequence similarity to human nuclear mRNA export factor 5. Tfb6 dissociates from TFIIH as a heterodimer with the Ssl2 subunit, a DNA helicase that drives promoter melting for the initiation of transcription. Tfb6 does not, however, dissociate Ssl2 from TFIIH in the context of a fully assembled transcription preinitiation complex. Our findings suggest a dynamic state of Ssl2, allowing its engagement in multiple cellular processes.

SUBMITTER: Murakami K 

PROVIDER: S-EPMC3323989 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC3277522 | biostudies-literature
| S-EPMC4541409 | biostudies-literature
| S-EPMC6078178 | biostudies-literature
| S-EPMC4314353 | biostudies-literature
| S-EPMC3688513 | biostudies-literature
| S-EPMC3957945 | biostudies-literature
| S-EPMC4560838 | biostudies-literature
| S-EPMC7669588 | biostudies-literature
| S-EPMC4281563 | biostudies-literature
| S-EPMC1863445 | biostudies-literature