Ontology highlight
ABSTRACT:
SUBMITTER: Devaraj NK
PROVIDER: S-EPMC3324005 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Devaraj Neal K NK Thurber Greg M GM Keliher Edmund J EJ Marinelli Brett B Weissleder Ralph R
Proceedings of the National Academy of Sciences of the United States of America 20120312 13
There has been intense interest in the development of selective bioorthogonal reactions or "click" chemistry that can proceed in live animals. Until now however, most reactions still require vast surpluses of reactants because of steep temporal and spatial concentration gradients. Using computational modeling and design of pharmacokinetically optimized reactants, we have developed a predictable method for efficient in vivo click reactions. Specifically, we show that polymer modified tetrazines ( ...[more]