Ontology highlight
ABSTRACT:
SUBMITTER: Lamming DW
PROVIDER: S-EPMC3324089 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Lamming Dudley W DW Ye Lan L Katajisto Pekka P Goncalves Marcus D MD Saitoh Maki M Stevens Deanna M DM Davis James G JG Salmon Adam B AB Richardson Arlan A Ahima Rexford S RS Guertin David A DA Sabatini David M DM Baur Joseph A JA
Science (New York, N.Y.) 20120301 6076
Rapamycin, an inhibitor of mechanistic target of rapamycin complex 1 (mTORC1), extends the life spans of yeast, flies, and mice. Calorie restriction, which increases life span and insulin sensitivity, is proposed to function by inhibition of mTORC1, yet paradoxically, chronic administration of rapamycin substantially impairs glucose tolerance and insulin action. We demonstrate that rapamycin disrupted a second mTOR complex, mTORC2, in vivo and that mTORC2 was required for the insulin-mediated su ...[more]