Deficient binocular combination reveals mechanisms of anisometropic amblyopia: signal attenuation and interocular inhibition.

ABSTRACT: Amblyopia is a developmental disorder that results in deficits of monocular and binocular vision. It is presently unclear whether these deficits result from attenuation of signals in the amblyopic eye, inhibition by signals in the fellow eye, or both. In this study, we characterize mechanisms underlying anisometropic amblyopia using a binocular phase and contrast combination paradigm and a contrast gain control model. Subjects dichoptically viewed two slightly different images and reported the perceived contrast and phase of the resulting cyclopean percept. We found that the properties of binocular combination were abnormal in many aspects in amblyopic vision. The observed abnormalities can be explained by a combination of (1) attenuated monocular signal in the amblyopic eye, (2) stronger

SUBMITTER: Huang CB 

PROVIDER: S-EPMC3324098 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature