Ontology highlight
ABSTRACT:
SUBMITTER: Hanna RN
PROVIDER: S-EPMC3324395 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Hanna Richard N RN Carlin Leo M LM Hubbeling Harper G HG Nackiewicz Dominika D Green Angela M AM Punt Jennifer A JA Geissmann Frederic F Hedrick Catherine C CC
Nature immunology 20110703 8
The transcription factors that regulate differentiation into the monocyte subset in bone marrow have not yet been identified. Here we found that the orphan nuclear receptor NR4A1 controlled the differentiation of Ly6C- monocytes. Ly6C- monocytes, which function in a surveillance role in circulation, were absent from Nr4a1-/- mice. Normal numbers of myeloid progenitor cells were present in Nr4a1-/- mice, which indicated that the defect occurred during later stages of monocyte development. The def ...[more]