Interaction and exposure modification: are we asking the right questions?
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ABSTRACT:
SUBMITTER: Weinberg CR
PROVIDER: S-EPMC3324436 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Publications
Interaction and exposure modification: are we asking the right questions?
American journal of epidemiology 20120203 7
Most diseases arise not purely through genetic abnormalities nor purely through environmental causes, but as "complex" conditions brought about by the combined effects of genetic susceptibility factors, nongenetic experiences and exposures, and bad luck. Finding simple models capable of both characterizing such joint effects and providing new insight into pathogenesis remains an ongoing challenge in etiologic epidemiology. Additive null models can capture certain pure forms of independent etiolo ...[more]
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