Ontology highlight
ABSTRACT:
SUBMITTER: Dibra D
PROVIDER: S-EPMC3324657 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Dibra Denada D Cutrera Jeffry J JJ Li Shulin S
Journal of immunology (Baltimore, Md. : 1950) 20120309 8
IL-30, the p28 subunit of IL-27, interacts with EBV-induced gene 3 to form IL-27, which modulates both proinflammatory and anti-inflammatory responses during autoimmune or infectious disease. It also acts as a natural antagonist of gp130, thereby attenuating the signals of other gp130-associated cytokines. IL-30 regulation via LPS has been reported by others, but the intercellular communication that induces IL-30 expression is unknown. In this study, we show that treatment with anti-CD3/CD28 Abs ...[more]