Brief report: the dopamine-3-receptor gene (DRD3) is associated with specific repetitive behavior in autism spectrum disorder (ASD).
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ABSTRACT:
SUBMITTER: Staal WG
PROVIDER: S-EPMC3324694 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
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Brief report: the dopamine-3-receptor gene (DRD3) is associated with specific repetitive behavior in autism spectrum disorder (ASD).
Staal Wouter G WG de Krom Mariken M de Jonge Maretha V MV
Journal of autism and developmental disorders 20120501 5
Recently the DRD3 gene has been associated with ASD in two independent samples. Follow up analysis of the risk allele of the SNP rs167771 in 91 subjects revealed a significant association with a specific type of repetitive behavior: the factor "insistence on sameness" (IS) derived from the Autism Diagnostic Interview. This risk allele was associated with a decreased risk for IS, but not with any other symptomatology. Further study and replication of this finding is necessary, bearing in mind tha ...[more]
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