Ontology highlight
ABSTRACT:
SUBMITTER: Choudhary A
PROVIDER: S-EPMC3324761 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Protein science : a publication of the Protein Society 20111221 2
The chromophore of fluorescent proteins, including the green fluorescent protein (GFP), contains a highly conjugated imidazolidinone ring. In many fluorescent proteins, the carbonyl group of the imidazolidinone ring engages in a hydrogen bond with the side chain of an arginine residue. Prior studies have indicated that such an electrophilic carbonyl group in a protein often accepts electron density from a main-chain oxygen. A survey of high-resolution structures of fluorescent proteins indicates ...[more]