Protein topology from predicted residue contacts.
Ontology highlight
ABSTRACT:
SUBMITTER: Taylor WR
PROVIDER: S-EPMC3324774 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Publications
Protein topology from predicted residue contacts.
Taylor William R WR Jones David T DT Sadowski Michael I MI
Protein science : a publication of the Protein Society 20111221 2
Residue contacts predicted from correlated positions in a multiple sequence alignment are often sparse and uncertain. To some extent, these limitations in the data can be overcome by grouping the contacts by secondary structure elements and enumerating the possible packing arrangements of these elements in a combinatorial manner. Strong interactions appear frequently but inconsistent interactions are down-weighted and missing interactions up-weighted. The resulting improved consistency in the pr ...[more]
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