Ontology highlight
ABSTRACT:
SUBMITTER: Matsson P
PROVIDER: S-EPMC3325368 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
The pharmacogenomics journal 20110308 3
ATP-binding cassette (ABC) membrane transporters determine the disposition of many drugs, metabolites and endogenous compounds. Coding region variation in ABC transporters is the cause of many genetic disorders, but much less is known about the genetic basis and functional outcome of ABC transporter expression level variation. We used genotype and mRNA transcript level data from human lymphoblastoid cell lines to assess population and gender differences in ABC transporter expression, and to guid ...[more]