Ontology highlight
ABSTRACT:
SUBMITTER: Macindoe I
PROVIDER: S-EPMC3325668 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Macindoe Ingrid I Kwan Ann H AH Ren Qin Q Morris Vanessa K VK Yang Wenrong W Mackay Joel P JP Sunde Margaret M
Proceedings of the National Academy of Sciences of the United States of America 20120123 14
The hydrophobin EAS from the fungus Neurospora crassa forms functional amyloid fibrils called rodlets that facilitate spore formation and dispersal. Self-assembly of EAS into fibrillar rodlets occurs spontaneously at hydrophobic:hydrophilic interfaces and the rodlets further associate laterally to form amphipathic monolayers. We have used site-directed mutagenesis and peptide experiments to identify the region of EAS that drives intermolecular association and formation of the cross-β rodlet stru ...[more]