Ontology highlight
ABSTRACT:
SUBMITTER: Zhao J
PROVIDER: S-EPMC3325682 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Zhao Jie J Jitkaew Siriporn S Cai Zhenyu Z Choksi Swati S Li Qiuning Q Luo Ji J Liu Zheng-Gang ZG
Proceedings of the National Academy of Sciences of the United States of America 20120315 14
Tumor necrosis factor (TNF) is an important inflammatory cytokine and induces many cellular responses, including inflammation, cell proliferation, apoptosis, and necrosis. It is known that receptor interacting protein (RIP) kinases, RIP1 and RIP3, are key effectors of TNF-induced necrosis, but little is known about how these two RIP kinases mediate this process, although reactive oxygen species (ROS) generation and JNK activation have been suggested to be two downstream events of RIP kinases. He ...[more]