Ontology highlight
ABSTRACT:
SUBMITTER: Kapp GT
PROVIDER: S-EPMC3325720 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Kapp Gregory T GT Liu Sen S Stein Amelie A Wong Derek T DT Reményi Attila A Yeh Brian J BJ Fraser James S JS Taunton Jack J Lim Wendell A WA Kortemme Tanja T
Proceedings of the National Academy of Sciences of the United States of America 20120307 14
Signaling pathways depend on regulatory protein-protein interactions; controlling these interactions in cells has important applications for reengineering biological functions. As many regulatory proteins are modular, considerable progress in engineering signaling circuits has been made by recombining commonly occurring domains. Our ability to predictably engineer cellular functions, however, is constrained by complex crosstalk observed in naturally occurring domains. Here we demonstrate a strat ...[more]