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Structure of AKR1C3 with 3-phenoxybenzoic acid bound.

ABSTRACT: Aldo-keto reductase 1C3 (AKR1C3) is a human enzyme that catalyzes the NADPH-dependent reduction of steroids and prostaglandins. AKR1C3 overexpression is associated with the proliferation of hormone-dependent cancers, most notably breast and prostate cancers. Nonsteroidal anti-inflammatory drugs (NSAIDs) and their analogues are well characterized inhibitors of AKR1C3. Here, the X-ray crystal structure of 3-phenoxybenzoic acid in complex with AKR1C3 is presented. This structure provides useful information for the future development of new anticancer agents by structure-guided drug design.

SUBMITTER: Jackson VJ

PROVIDER: S-EPMC3325808 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature

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Structure of AKR1C3 with 3-phenoxybenzoic acid bound.

Jackson Victoria J VJ Yosaatmadja Yuliana Y Flanagan Jack U JU Squire Christopher J CJ

Acta crystallographica. Section F, Structural biology and crystallization communications 20120327 Pt 4

Aldo-keto reductase 1C3 (AKR1C3) is a human enzyme that catalyzes the NADPH-dependent reduction of steroids and prostaglandins. AKR1C3 overexpression is associated with the proliferation of hormone-dependent cancers, most notably breast and prostate cancers. Nonsteroidal anti-inflammatory drugs (NSAIDs) and their analogues are well characterized inhibitors of AKR1C3. Here, the X-ray crystal structure of 3-phenoxybenzoic acid in complex with AKR1C3 is presented. This structure provides useful inf ...[more]

PMID: 22505408

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