Ontology highlight
ABSTRACT:
SUBMITTER: Li X
PROVIDER: S-EPMC3326223 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Li X X Lu Y Y Liang K K Hsu J-M JM Albarracin C C Mills G B GB Hung M-C MC Fan Z Z
Oncogene 20120109 40
Epidermal growth factor receptor (EGFR)-mediated cell signaling is critical for mammary epithelial cell growth and survival; however, targeting EGFR has shown no or only minimal therapeutic benefit in patients with breast cancer. Here, we report a novel regulatory mechanism of EGFR signaling that may explain the low response rates. We found that breast tumor kinase (Brk)/protein-tyrosine kinase 6 (PTK6), a nonreceptor protein-tyrosine kinase highly expressed in most human breast tumors, interact ...[more]