Ontology highlight
ABSTRACT:
SUBMITTER: Sacconi L
PROVIDER: S-EPMC3326470 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Sacconi Leonardo L Ferrantini Cecilia C Lotti Jacopo J Coppini Raffaele R Yan Ping P Loew Leslie M LM Tesi Chiara C Cerbai Elisabetta E Poggesi Corrado C Pavone Francesco S FS
Proceedings of the National Academy of Sciences of the United States of America 20120326 15
The plasma membrane of cardiac myocytes presents complex invaginations known as the transverse-axial tubular system (TATS). Despite TATS's crucial role in excitation-contraction coupling and morphological alterations found in pathological settings, TATS's electrical activity has never been directly investigated in remodeled tubular networks. Here we develop an ultrafast random access multiphoton microscope that, in combination with a customly synthesized voltage-sensitive dye, is used to simulta ...[more]