Ontology highlight
ABSTRACT:
SUBMITTER: Kurnik M
PROVIDER: S-EPMC3326513 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Kurnik Martin M Hedberg Linda L Danielsson Jens J Oliveberg Mikael M
Proceedings of the National Academy of Sciences of the United States of America 20120327 15
Surface charges of proteins have in several cases been found to function as "structural gatekeepers," which avoid unwanted interactions by negative design, for example, in the control of protein aggregation and binding. The question is then if side-chain charges, due to their desolvation penalties, play a corresponding role in protein folding by avoiding competing, misfolded traps? To find out, we removed all 32 side-chain charges from the 101-residue protein S6 from Thermus thermophilus. The re ...[more]