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The PRINTS database: a fine-grained protein sequence annotation and analysis resource--its status in 2012.


ABSTRACT: The PRINTS database, now in its 21st year, houses a collection of diagnostic protein family 'fingerprints'. Fingerprints are groups of conserved motifs, evident in multiple sequence alignments, whose unique inter-relationships provide distinctive signatures for particular protein families and structural/functional domains. As such, they may be used to assign uncharacterized sequences to known families, and hence to infer tentative functional, structural and/or evolutionary relationships. The February 2012 release (version 42.0) includes 2156 fingerprints, encoding 12?444 individual motifs, covering a range of globular and membrane proteins, modular polypeptides and so on. Here, we report the current status of the database, and introduce a number of recent developments that help both to render a variety of our annotation and analysis tools easier to use and to make them more widely available. Database URL: www.bioinf.manchester.ac.uk/dbbrowser/PRINTS/.

SUBMITTER: Attwood TK 

PROVIDER: S-EPMC3326521 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

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The PRINTS database: a fine-grained protein sequence annotation and analysis resource--its status in 2012.

Attwood Teresa K TK   Coletta Alain A   Muirhead Gareth G   Pavlopoulou Athanasia A   Philippou Peter B PB   Popov Ivan I   Romá-Mateo Carlos C   Theodosiou Athina A   Mitchell Alex L AL  

Database : the journal of biological databases and curation 20120415


The PRINTS database, now in its 21st year, houses a collection of diagnostic protein family 'fingerprints'. Fingerprints are groups of conserved motifs, evident in multiple sequence alignments, whose unique inter-relationships provide distinctive signatures for particular protein families and structural/functional domains. As such, they may be used to assign uncharacterized sequences to known families, and hence to infer tentative functional, structural and/or evolutionary relationships. The Feb  ...[more]

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