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Common breast cancer susceptibility loci are associated with triple-negative breast cancer.


ABSTRACT: Triple-negative breast cancers are an aggressive subtype of breast cancer with poor survival, but there remains little known about the etiologic factors that promote its initiation and development. Commonly inherited breast cancer risk factors identified through genome-wide association studies display heterogeneity of effect among breast cancer subtypes as defined by the status of estrogen and progesterone receptors. In the Triple Negative Breast Cancer Consortium (TNBCC), 22 common breast cancer susceptibility variants were investigated in 2,980 Caucasian women with triple-negative breast cancer and 4,978 healthy controls. We identified six single-nucleotide polymorphisms, including rs2046210 (ESR1), rs12662670 (ESR1), rs3803662 (TOX3), rs999737 (RAD51L1), rs8170 (19p13.1), and rs8100241 (19p13.1), significantly associated with the risk of triple-negative breast cancer. Together, our results provide convincing evidence of genetic susceptibility for triple-negative breast cancer.

SUBMITTER: Stevens KN 

PROVIDER: S-EPMC3327299 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature

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Common breast cancer susceptibility loci are associated with triple-negative breast cancer.

Stevens Kristen N KN   Vachon Celine M CM   Lee Adam M AM   Slager Susan S   Lesnick Timothy T   Olswold Curtis C   Fasching Peter A PA   Miron Penelope P   Eccles Diana D   Carpenter Jane E JE   Godwin Andrew K AK   Ambrosone Christine C   Winqvist Robert R   Brauch Hiltrud H   Schmidt Marjanka K MK   Cox Angela A   Cross Simon S SS   Sawyer Elinor E   Hartmann Arndt A   Beckmann Matthias W MW   Schulz-Wendtland Rüdiger R   Ekici Arif B AB   Tapper William J WJ   Gerty Susan M SM   Durcan Lorraine L   Graham Nikki N   Hein Rebecca R   Nickels Stephan S   Flesch-Janys Dieter D   Heinz Judith J   Sinn Hans-Peter HP   Konstantopoulou Irene I   Fostira Florentia F   Pectasides Dimitrios D   Dimopoulos Athanasios M AM   Fountzilas George G   Clarke Christine L CL   Balleine Rosemary R   Olson Janet E JE   Fredericksen Zachary Z   Diasio Robert B RB   Pathak Harsh H   Ross Eric E   Weaver JoEllen J   Rüdiger Thomas T   Försti Asta A   Dünnebier Thomas T   Ademuyiwa Foluso F   Kulkarni Swati S   Pylkäs Katri K   Jukkola-Vuorinen Arja A   Ko Yon-Dschun YD   Van Limbergen Erik E   Janssen Hilde H   Peto Julian J   Fletcher Olivia O   Giles Graham G GG   Baglietto Laura L   Verhoef Senno S   Tomlinson Ian I   Kosma Veli-Matti VM   Beesley Jonathan J   Greco Dario D   Blomqvist Carl C   Irwanto Astrid A   Liu Jianjun J   Blows Fiona M FM   Dawson Sarah-Jane SJ   Margolin Sara S   Mannermaa Arto A   Martin Nicholas G NG   Montgomery Grant W GW   Lambrechts Diether D   dos Santos Silva Isabel I   Severi Gianluca G   Hamann Ute U   Pharoah Paul P   Easton Douglas F DF   Chang-Claude Jenny J   Yannoukakos Drakoulis D   Nevanlinna Heli H   Wang Xianshu X   Couch Fergus J FJ  

Cancer research 20110815 19


Triple-negative breast cancers are an aggressive subtype of breast cancer with poor survival, but there remains little known about the etiologic factors that promote its initiation and development. Commonly inherited breast cancer risk factors identified through genome-wide association studies display heterogeneity of effect among breast cancer subtypes as defined by the status of estrogen and progesterone receptors. In the Triple Negative Breast Cancer Consortium (TNBCC), 22 common breast cance  ...[more]

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