Ontology highlight
ABSTRACT:
SUBMITTER: Du J
PROVIDER: S-EPMC3327457 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Du Jinwei J Chen Yu Y Li Qiang Q Han Xiangzi X Cheng Cindy C Wang Zhengqi Z Danielpour David D Dunwoodie Sally L SL Bunting Kevin D KD Yang Yu-Chung YC
Blood 20120202 12
Cited2 is a transcriptional modulator involved in various biologic processes including fetal liver hematopoiesis. In the present study, the function of Cited2 in adult hematopoiesis was investigated in conditional knockout mice. Deletion of Cited2 using Mx1-Cre resulted in increased hematopoietic stem cell (HSC) apoptosis, loss of quiescence, and increased cycling, leading to a severely impaired reconstitution capacity as assessed by 5-fluorouracil treatment and long-term transplantation. Transc ...[more]