Ontology highlight
ABSTRACT:
SUBMITTER: Cardamone MD
PROVIDER: S-EPMC3327812 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Cardamone M Dafne MD Krones Anna A Tanasa Bogdan B Taylor Havilah H Ricci Laura L Ohgi Kenneth A KA Glass Christopher K CK Rosenfeld Michael G MG Perissi Valentina V
Molecular cell 20120315 1
The association between hyperinflammatory states and numerous diseases is widely recognized, but our understanding of the molecular strategies that have evolved to prevent uncontrolled activation of inflammatory responses remains incomplete. Here, we report a critical, nontranscriptional role of GPS2 as a guardian against hyperstimulation of the TNF-α-induced gene program. GPS2 cytoplasmic actions are required to specifically modulate RIP1 ubiquitylation and JNK activation by inhibiting TRAF2/Ub ...[more]