Ontology highlight
ABSTRACT:
SUBMITTER: Tamada M
PROVIDER: S-EPMC3327890 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Tamada Masako M Farrell Dene L DL Zallen Jennifer A JA
Developmental cell 20120201 2
Interactions between epithelial cells are mediated by adherens junctions that are dynamically regulated during development. Here we show that the turnover of β-catenin is increased at cell interfaces that are targeted for disassembly during Drosophila axis elongation. The Abl tyrosine kinase is concentrated at specific planar junctions and is necessary for polarized β-catenin localization and dynamics. abl mutant embryos have decreased β-catenin turnover at shrinking edges, and these defects are ...[more]