Ontology highlight
ABSTRACT:
SUBMITTER: Kwan KY
PROVIDER: S-EPMC33279 | biostudies-literature | 2001 May
REPOSITORIES: biostudies-literature
Proceedings of the National Academy of Sciences of the United States of America 20010501 10
Targeted gene disruption in the murine TOP3beta gene-encoding DNA topoisomerase IIIbeta was carried out. In contrast to the embryonic lethality of mutant mice lacking DNA topoisomerase IIIalpha, top3beta(-/-) nulls are viable and grow to maturity with no apparent defects. Mice lacking DNA topoisomerase IIIbeta have a shorter life expectancy than their wild-type littermates, however. The mean lifespan of the top3beta(-/-) mice is about 15 months, whereas that of their wild-type littermates is lon ...[more]