The phospholipase D1 pathway modulates macroautophagy.
Ontology highlight
ABSTRACT:
SUBMITTER: Dall'Armi C
PROVIDER: S-EPMC3328354 | biostudies-literature | 2010
REPOSITORIES: biostudies-literature
Publications
The phospholipase D1 pathway modulates macroautophagy.
Dall'Armi Claudia C Hurtado-Lorenzo Andrés A Tian Huasong H Morel Etienne E Nezu Akiko A Chan Robin B RB Yu W Haung WH Robinson Kimberly S KS Yeku Oladapo O Small Scott A SA Duff Karen K Frohman Michael A MA Wenk Markus R MR Yamamoto Akitsugu A Di Paolo Gilbert G
Nature communications 20100101
Although macroautophagy is known to be an essential degradative process whereby autophagosomes mediate the engulfment and delivery of cytoplasmic components into lysosomes, the lipid changes underlying autophagosomal membrane dynamics are undetermined. Here, we show that phospholipase D1 (PLD1), which is primarily associated with the endosomal system, partially relocalizes to the outer membrane of autophagosome-like structures upon nutrient starvation. The localization of PLD1, as well as the st ...[more]
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2023-08-01 | GSE207281 | GEO
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