Ontology highlight
ABSTRACT:
SUBMITTER: Donovan J
PROVIDER: S-EPMC3328465 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Donovan Jesse J Copeland Paul R PR
PloS one 20120417 4
The amino acid selenocysteine (Sec) is encoded by UGA codons. Recoding of UGA from stop to Sec requires a Sec insertion sequence (SECIS) element in the 3' UTR of selenoprotein mRNAs. SECIS binding protein 2 (SBP2) binds the SECIS element and is essential for Sec incorporation into the nascent peptide. SBP2-like (SBP2L) is a paralogue of SBP2 in vertebrates and is the only SECIS binding protein in some invertebrates where it likely directs Sec incorporation. However, vertebrate SBP2L does not pro ...[more]