Ontology highlight
ABSTRACT:
SUBMITTER: Yang H
PROVIDER: S-EPMC3328696 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Yang Huaiyu H Gao Zhaobing Z Li Ping P Yu Kunqian K Yu Ye Y Xu Tian-Le TL Li Min M Jiang Hualiang H
Biophysical journal 20120401 8
Voltage sensing confers conversion of a change in membrane potential to signaling activities underlying the physiological processes. For an ion channel, voltage sensitivity is usually experimentally measured by fitting electrophysiological data to Boltzmann distributions. In our study, a two-state model of the ion channel and equilibrium statistical mechanics principle were used to test the hypothesis of empirically calculating the overall voltage sensitivity of an ion channel on the basis of it ...[more]