Ontology highlight
ABSTRACT:
SUBMITTER: Ferrada E
PROVIDER: S-EPMC3328697 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Ferrada Evandro E Wagner Andreas A
Biophysical journal 20120401 8
The relationship between the genotype (sequence) and the phenotype (structure) of macromolecules affects their ability to evolve new structures and functions. We here compare the genotype space organization of proteins and RNA molecules to identify differences that may affect this ability. To this end, we computationally study the genotype-phenotype relationship for short RNA and lattice proteins of a reduced monomer alphabet size, to make exhaustive analysis and direct comparison of their genot ...[more]